NFL Week 5 Picks: Early Odds Tips, Spreads and Predictions for Latest Schedule

October 5, 2015   ·   Michelle Bruton   ·   Jump to comments

Although Week 4 of the NFL season featured some compelling matchups—from an intra-division battle between the Arizona Cardinals and St. Louis Rams, which the Rams won in a shocker, to a bad-blood rematch between the San Francisco 49ers and the Green Bay Packers—Week 5 appears to be more straightforward. 
Seven of the upcoming Week 5 matchups feature point spreads of a touchdown or more, following in the theme of the week, which appears to be top dogs versus underdogs.
There are a few games that promise some intrigue, and as we know well, anything can happen on any given Sunday in the NFL, but on paper, Week 5 seems like a good one for those in survivor pools and betting against the spread. 
Let's make picks and review odds for all Week 5 games, as well as preview some must-see matchups. 
 
Must-See Matchups Indianapolis Colts at Houston Texans 
In one of this week's few divisional matchups, the Indianapolis Colts pote...

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